HL-60 Cell Differentiation and Osteopontin Expression
نویسندگان
چکیده
منابع مشابه
The HL - 60 Promyelocytic Leukemia Cell Line : Proliferation , Differentiation , and Cellular Oncogene Expression By Steven
A LTHOUGH LEUKEMIC cells from patients with acute myeloid leukemia display a seemingly unlimited proliferative capacity in vivo, their life span in liquid suspension culture is usually limited to a few cell divisions. One possible explanation for such limited in vitro proliferation is that certain growth factors sustaining leukemic cell division in the patient are absent from the in vitro cultu...
متن کاملThe HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression.
The HL-60 cell line, derived from a single patient with acute promyelocytic leukemia, provides a unique in vitro model system for studying the cellular and molecular events involved in the proliferation and differentiation of normal and leukemic cells of the granulocyte/monocyte/macrophage lineage.
متن کاملAn Effective Model of HL-60 Differentiation
We present an effective model All-Trans Retinoic Acid (ATRA)-induced differentiation of HL-60 cells. The model describes a key architectural feature of ATRA-induced differentiation, positive feedback between an ATRA-inducible signalsome complex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation of the mitogen activated protein kinase (MAPK) cascade....
متن کاملEffects of tiazofurin on protooncogene expression during HL-60 cell differentiation.
The synthetic nucleoside analogue, tiazofurin (2-beta-D-ribofuranosylthiazole-4-carboxamide, NSC 286193) is an inhibitor of the enzyme inosine monophosphate (IMP) dehydrogenase and depletes guanine nucleotide pools. In the present study, we have monitored the effects of tiazofurin on human HL-60 promyelocytic cell differentiation and protooncogene expression. Tiazofurin (10 microM) induced a mo...
متن کاملDifferentiation-linked expression of cell surface markers on HL-60 leukemic cells.
The cell surface antigenic phenotype of HL-60, a human acute promyelocytic leukemia cell line, has been analyzed before and after maturation induction with dimethylsulfoxide (DMSO) using a panel of markers including a "library" of monoclonal antibodies and "conventional" antisera in conjunction with the fluorescene-activated cell sorter. HL-60 cells express granulocyte and "leukocyte" different...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 1995
ISSN: 0077-8923,1749-6632
DOI: 10.1111/j.1749-6632.1995.tb44641.x